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KMID : 1234920090090010071
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Journal of Korean Oriental Association for Study of Obesity
2009 Volume.9 No. 1 p.71 ~ p.78
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A Study on the Acute Toxicity of Bangpungtongsung-san(Fangfengtongsheng-San) in Mice
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Lee Jae-Hoon
Shim Ki-Shuk
Park Hwa-yong
Jeon Won-kyung
Um Young-Ran
Ma Jin-Yeul
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Abstract
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Objectives : Bangpungtongsung-san(Fangfengtongsheng-san) has been traditionally prescribed a a restorative medicine.
Methods : In this study, we investigated the acute toxicity of water-extracted Bangpungtongsung-san(Fangfengtongsheng-san). 20 male and 20 female mice were orally treated of Bangpungtongsung-san(Fangfengtongsheng-san) at the respective doses of 0 (control group), 1250, 2500 and 5000mg/kg for 14days.
Results : We observed survival rates, general toxicity, change of body weight and examined microscopic changes of some organs.
Conclusions :Compared with the control group, we could no find any toxic alteration in all treated groups (1250, 2500 and 500mg/kg). of Bangpungtongsung-san(Fangfengtongsheng-san) might be over 5000mg/kg and it was very safe to ICR mice.
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KEYWORD
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Bangpungtongsung-san(Fangfengtongsheng-san), Acute toxicity, safety
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